Examples of 'modified nucleotide' in a sentence
Meaning of "modified nucleotide"
modified nucleotide: A nucleotide that has been chemically altered or enhanced from its original form. Modified nucleotides are often used in molecular biology and genetics research to study gene expression, protein synthesis, and other biological processes
How to use "modified nucleotide" in a sentence
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modified nucleotide
The modified groups can be modified nucleotide bases.
The modified nucleotide may confer nuclease resistance to the oligonucleotide.
The changes are limited to the modified nucleotide itself.
Natural and modified nucleotide monomers for the chemical synthesis of nucleic acids are readily available.
Aptamers may comprise at least one modified nucleotide base.
The use of hydroxymethyl modified nucleotide monomers may be favoured for several reasons.
One or more of the monomers in the mixture may comprise a modified nucleotide.
In another approach such a modified nucleotide may be removed enzymatically.
In a preferred embodiment the nucleotide at the position of the mismatch is not a modified nucleotide.
Nucleic acids having modified nucleotide residues exist in nature.
Method according to any of the previous claims wherein the mismatch is not a modified nucleotide.
A polynucleotide may comprise one modified nucleotide or multiple modified nucleotides.
The dsRNA of the present invention may further comprise a subsituted or chemically modified nucleotide.
The protected modified nucleotide is then incorporated vÃa standard phosphoramidite chemistry into a growing nucleic acid.
The double stranded ribonucleic acid molecule may comprise at least one chemically modified nucleotide.
See also
DNA having a modified nucleotide sequence can be artificially synthesized.
The RNA molecule according to the invention contains at least one modified nucleotide analogue.
DNA polymerases having modified nucleotide binding site for DNA sequencing.
In another embodiment, the dsNA includes a modified nucleotide.
Incorporating a first modified nucleotide into a nucleic acid strand ;.
In some embodiments, the fluorophore is attached to the modified nucleotide.
R ' of the modified nucleotide or nucleoside can be an alkyl or substituted alkyl.
A non-nucleotide residue and a modified nucleotide residue.
The modified nucleotide or nucleoside molecule of claim 8, wherein the detectable label is a fluorophore.
Table 5 below indicates the modified nucleotide loaded in each lane.
In one embodiment, the siRNA comprises at least one modified nucleotide.
In some embodiments, the modified nucleotide does not comprise a fluorescent moiety.
Particularly, the overhangs may be stabilized by incorporating modified nucleotide analogues.
A method of making a modified nucleotide as claimed in claim 1 comprising the steps of,.
Particularly, the ends may be stabilized by incorporating modified nucleotide analogues.
In some embodiments, the modified nucleotide confers nuclease resistance to the oligonucleotide.
In certain embodiments, the siRNA comprises at least one modified nucleotide.
The method of claim 8, wherein said modified nucleotide is an arabinose nucleotide.
In some embodiments, the dsRNA comprises at least one modified nucleotide.
A kit according to claim 28 wherein the modified nucleotide comprises a methylated nucleotide.
For example, the discontinuity is flanked on either side by a phosphorothioate modified nucleotide.
An oligonucleotide according to claim 3 wherein the modified nucleotide base has an a-anomer conformation.
In another embodiment, the discontinuity is flanked on either side by a phosphorothioate modified nucleotide.
The dsRNA of claim 4, wherein said chemically modified nucleotide is a locked nucleotide.
A modified nucleotide comprises a modification in one or more of the sugar, phosphate and or base.
In an example of the disclosure, the dsNA comprises at least one modified nucleotide.
In another preferred embodiment, the modified nucleotide comprises a nucleotide having a phosphorothioate linkage.
Hence a reaction mixture is formed, which includes the modified nucleotide sugar.
The modified nucleotide residue may be a residue of an alternative of the nucleotide, for example.
In some embodiments, the siRNA molecule comprises at least one modified nucleotide.
An aptamer comprising at least one modified nucleotide having the following structure, wherein.
A modified nucleotide which contains a base modification is also called a base-modified nucleotide.
The method of claim 1, wherein the modified nucleotide does not comprise a fluorescent moiety.
The method of claim 1, wherein the dsRNA comprises at least one modified nucleotide.
Contacting a reaction mixture comprising said modified nucleotide sugar with an anion exchange medium ;.
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