Examples of 'modified oligonucleotides' in a sentence
Meaning of "modified oligonucleotides"
modified oligonucleotides - These are altered versions of DNA or RNA molecules, where changes are made to the nucleotide sequence. They are often used in genetic research, molecular biology, and biotechnology for various purposes such as gene expression studies, therapeutic developments, or diagnostics
How to use "modified oligonucleotides" in a sentence
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modified oligonucleotides
Labeling of the ends with modified oligonucleotides.
These modified oligonucleotides are reported to be resistant to exonuclease activity.
Ribozymes may comprise modified oligonucleotides e.
Modified oligonucleotides for telomerase inhibition.
The antisense nucleic acids include modified oligonucleotides.
Modified oligonucleotides may be preferred in some antisense applications.
Preparation and purification of modified oligonucleotides.
Disclose chemically modified oligonucleotides for modulating expression of microRNAs.
The assay requires a minimum of two modified oligonucleotides.
Such modified oligonucleotides are attractive because of increased stability to nucleases.
Improved targeted nucleotide exchange with propynyl modified oligonucleotides.
Probes containing modified oligonucleotides may also be useful.
Improved targeted nucleotide exchange with ina modified oligonucleotides.
These modified oligonucleotides also yield increased mismatch discrimination.
The antisense nucleic acids of present invention include modified oligonucleotides.
See also
These modified oligonucleotides are then immobilized on the attachment zone by electrografting.
The antisense nucleic acids of present disclosure include modified oligonucleotides.
Described herein is the use of modified oligonucleotides as probes in a hybridization assay.
The antisense nucleic acids as disclosed herein include modified oligonucleotides.
Chemically modified oligonucleotides have been used to enhance their nuclease stability.
The probes and primers of the invention are optionally modified oligonucleotides.
Oligonucleotide and modified oligonucleotides are commercially available from numerous companies.
Duplex stabilization has been observed with several carbohydrate modified oligonucleotides.
These modified oligonucleotides have been shown to have increased half lives.
These methods have not proven suitable for separating modified oligonucleotides.
These modified oligonucleotides can be synthesized using standard chemical transformations.
The techniques for making oligonucleotides and modified oligonucleotides are known in the art.
The modified oligonucleotides are purified from the free nucleotides on a spin column.
Key to such methods is the use of modified oligonucleotides carrying reporter groups or labels.
Modified oligonucleotides may also contain one or more substituted or modified sugar moieties.
Various preferred embodiments of modified oligonucleotides according to the invention are discussed below.
The nucleotides according to the invention may comprise one or more modified oligonucleotides.
The sequences of novel modified oligonucleotides for the above method are as follows.
In particular the present invention concerns a labelling reagent for preparing a new class of modified oligonucleotides.
These modified oligonucleotides can be prepared by methods well known in the art.
Then the surface is brought into contact with modified oligonucleotides according to the invention.
The modified oligonucleotides can be prepared by means of routine solid phase synthesis techniques.
This example illustrates the enhanced ability of modified oligonucleotides to discriminate between related target sequences.
Modified oligonucleotides and oligonucleotide analogs may be less readily internalized than their natural counterparts.
The use of any preceding claim wherein the siNA comprises one or more modified oligonucleotides.
Several investigations have shown that such modified oligonucleotides are more effective than their unmodified counterparts.
In certain embodiments, it may be helpful to include one or more modified oligonucleotides.
The INA modified oligonucleotides are preferably immobilised onto said reactions body.
The ribozymes can be composed of modified oligonucleotides e . g.
Generally, modified oligonucleotides are first tested in cultured cells.
These may also be synthetic, possibly modified oligonucleotides.
It involves immobilizing modified oligonucleotides ( comprising a pyrrole group ) by electrografting.
In a preferred embodiment, the decoy probe is made up of optionally modified oligonucleotides.
It involves immobilizing modified oligonucleotides ( containing a pyrrole group ) by electrografting.
In certain disclosure herein, it may be helpful to include one or more modified oligonucleotides.
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Examples of using Oligonucleotides
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Longer oligonucleotides lead to increased transformation efficiency
Corresponding synthetic miRNA oligonucleotides were used as standards
Two oligonucleotides are constructed from this sequence
