Examples of 'nucleotide analogues' in a sentence
Meaning of "nucleotide analogues"
nucleotide analogues: This phrase refers to chemical compounds that are structurally similar to nucleotides, which are the building blocks of DNA and RNA. Nucleotide analogues are often used in scientific research or medical treatments to study or interfere with genetic processes
How to use "nucleotide analogues" in a sentence
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nucleotide analogues
Unfortunately said nucleotide analogues are rather expensive.
A polynucleotide can be composed of nucleotides or nucleotide analogues.
Nucleotide analogues are compared directly to their equivalent nucleotides.
Many methoxyphosphonate nucleotide analogues are known.
Nucleotide analogues for the treatment of viral infections.
Modified polymerases for improved incorporation of nucleotide analogues.
Nucleotide analogues are compared directly to their equivalent or corresponding nucleotides.
Modification for thymidine nucleosides and nucleotide analogues.
A wide variety of nucleotide analogues are compatible with the invention.
E groups represent the aglycons employed in the methoxyphosphonate nucleotide analogues.
Nucleoside and nucleotide analogues.
All these nucleotide analogues can be used as reactants for the synthesis of oligonucleotides.
Applications for enhanced incorporation of nucleotide analogues by a dna polymerase.
The use of nucleotide analogues may be favoured for several reasons.
The simple solution would be to administer the phosphorylated form of the nucleotide analogues.
See also
Many nucleoside and nucleotide analogues have been developed as antiviral agents.
The clamp probe may be DNA and RNA as well as nucleotide analogues.
The detection agent labelled nucleotide analogues are dye labelled analogues.
Some nucleotide analogues may also be able to mediate RNaseH binding and cleavage.
Not comprising one or more nucleotides or nucleotide analogues covalently attached to said compound.
Such nucleotide analogues may suitably enhance the affinity of the oligomer for the target sequence.
In one embodiment all the nucleotide analogues are INA.
The use of nucleotide analogues is also encompassed in the present invention.
Available therapies for HBV include IFN and nucleoside and nucleotide analogues.
Prodrugs of phosphonate nucleotide analogues and methods for selecting and making same.
These substances are classed as nucleoside and / or nucleotide analogues.
Very many chain termination nucleotide analogues are substrates for different DNA polymerases.
Suitably, all nucleotides are replaced by a corresponding nucleotide analogues.
LNAs are bicyclic and tricyclic nucleoside and nucleotide analogues and may be incorporated in oligonucleotides.
Nucleotide analogues forming part of the composition of synthetic oligonucleotides ;.
In recent years, many different nucleotide analogues have been generated.
Preferred nucleotide analogues are selected from sugar - or backbone-modified ribonucleotides.
Structure-activity studies of various nucleotide analogues have been reported.
Preferred nucleotide analogues are selected from sugar-or backbone-modified ribonucleotides.
In some embodiments the oligomer comprises at least 2 nucleotide analogues.
Some individual nucleotides and / or nucleotide analogues may be part of both regions.
In one embodiment the antisense strand comprises at least 2 nucleotide analogues.
Furthermore, the nucleotide analogues may enhance the stability of the oligomer in vivo.
In some cases fluorescent labeled nucleotides and / or nucleotide analogues are used.
Nucleotide analogues bypass this step, given that they are already chemically activated.
Particularly, the overhangs may be stabilized by incorporating modified nucleotide analogues.
In another embodiment, various different nucleotide analogues are used in the same antisense strand.
Particularly, the ends may be stabilized by incorporating modified nucleotide analogues.
Moreover, nucleotide analogues may be used for reasons related to cost or ease of synthesis.
In some embodiments, the contiguous nucleotide sequence consists of 9 nucleotide analogues.
Scheme 1 illustrates selected examples of nucleotide analogues suitable for making nucleic acids.
Accordingly, in a preferred embodiment, the antisense strand comprises nucleotide analogues.
In yet another embodiment, nucleotide analogues are also comprised for usage as primers and / or probes.
In another embodiment, all nucleotides of the antisense strand are nucleotide analogues.
In one embodiment, the nucleotide analogues confer enhanced serum stability to the single stranded oligonucleotide.
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