Examples of 'cpg motifs' in a sentence
Meaning of "cpg motifs"
cpg motifs - short, specific sequences of nucleotides found repeatedly in DNA
How to use "cpg motifs" in a sentence
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cpg motifs
Preferably the CpG motifs are unmethylated.
These oligonuclotides may be free from unmethylated CpG motifs.
Methylation or removal of all unmethylated CpG motifs in an oligonucleotide substantially reduces its effect.
These oligonucleotides may be free from unmethylated CpG motifs.
The CpG motifs may be modified by the methylation of at least one CPG motif.
These oligonucleotides maybe free from unmethylated CpG motifs.
Cells cultured with ODN that lacked CpG motifs did not induce cytokine secretion.
Oligonucleotides comprising at least one CpG motif can comprise multiple CpG motifs.
In preferred embodiments the plurality of CpG motifs and poly T motifs are interspersed.
However on a per plasmid basis this minimal replication fragment contributes significantly fewer CpG motifs.
In other aspects, the CpG motifs are methylated.
Synthetic DNA has also been reported to be immunostimulatory if it contains unmethylated CpG motifs.
In some embodiments the plurality of CpG motifs and poly-T motifs are interspersed.
In another embodiment, the Py-rich or TG oligonucleotide is free of a CpG motifs.
Therefore, the insertion of CpG motifs in plasmid sequences enhances the immune response.
See also
Both phosphorothioate and phosphodiester oligonucleotides containing CpG motifs are active in immune cells.
Elimination of CpG motifs can be achieved by deleting non-essential regions of the vector.
However, it is not increased by DNA that does not contain CpG motifs.
In one embodiment, CpG motifs of plasmid DNA may methylated to reduce the immunostimulatory response.
Immunostimulatory motifs include, but are not limited to CpG motifs and T-rich motifs.
Other organisms with hypomethylated CpG motifs have demonstrated the stimulation of polyclonal B-cell expansion.
The T-rich immunostimulatory nucleic acid may include one or more CpG motifs.
TLR9 recognises CpG motifs of bacterial DNA.
The poly-G immunostimulatory nucleic acid includes one or more CpG motifs or T-rich motifs.
Partial methylation of CpG motifs caused a partial loss of stimulatory effect ( compare 2a to 2c, Table 1 ).
The Py-rich and TG immunostimulatory nucleic acids of the invention may optionally include CpG motifs.
The preferred distance between individual CpG motifs is in the range of 1 to 200 nt.
Although bacterial DNA is immunostimulatory across many vertebrate species, the individual CpG motifs may differ.
As expected, within cultured Th1 cells CpG motifs were completely methylated ( Figure 2B ).
In mammals the TIR dedicated to the detection of non-methylated CpG motifs is TLR9.
Example 7 Effect of mutating immunostimulatory CpG motifs within pCF1-CAT.
One of these ‘ danger ' signals is a pattern characteristic of bacterial DNA, known as CpG motifs.
The plasmid of claim 5, further containing 8 CpG motifs.
Bacterially produced DNA, including i-DNA ™, contains unmethylated CpG motifs.
Oligo 1, which contains one CpG motif and Oligo 2, which contains two CpG motifs.
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