Examples of 'cpg oligonucleotide' in a sentence
Meaning of "cpg oligonucleotide"
cpg oligonucleotide: A short, single-stranded DNA molecule containing cytosine and guanine nucleotide bases connected by a phosphate backbone. These molecules play a crucial role in various biological processes, such as gene expression regulation and DNA methylation
How to use "cpg oligonucleotide" in a sentence
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cpg oligonucleotide
In some embodiments the agonist is a CpG oligonucleotide.
A CpG oligonucleotide can also contain a modified guanine.
In another embodiment the CpG oligonucleotide is free of a palindrome.
The CpG oligonucleotide and mucosal adjuvant may be administered simultaneously or sequentially.
The adjuvant may be a CpG oligonucleotide.
The other doses of CpG oligonucleotide may be administered mucosally or systemically.
Therapeutic methods of using such thermolabile CpG oligonucleotide prodrugs are described.
The entire CpG oligonucleotide can be unmethylated or portions may be unmethylated.
In another aspect the composition is an intranasal formulation of a CpG oligonucleotide in an aerosol.
In one embodiment the CpG oligonucleotide contains a palindromic sequence.
CpG oligonucleotide can act in a synergistic manner with other mucosal adjuvants to enhance immune responses.
This demonstrates that CpG oligonucleotide activates IPCs in vitro.
The CpG oligonucleotide can be administered in conjunction with another mucosal adjuvant.
Another preferred formulation comprises a CpG oligonucleotide alone or together with an aluminium salt.
Thus CpG oligonucleotide can induce specific local mucosal immunity against antigen administered intranasally.
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No detectable endotoxin was present in either CpG oligonucleotide by LAL assay.
In another embodiment the CpG oligonucleotide is administered with a boost dose of antigen.
In another embodiment, the adjuvant is a CpG oligonucleotide.
For instance the CpG oligonucleotide may be administered with a priming dose of antigen.
In another aspect, the adjuvant is a CpG oligonucleotide.
The synergistic interaction of CpG oligonucleotide with mucosal adjuvants has important implications in vaccine development.
In one embodiment, the adjuvant includes aluminum hydroxide gel and a CpG oligonucleotide.
A vaccine composition comprising an immunostimulatory CpG oligonucleotide and a polysaccharide antigen from Streptococcus pneumoniae.
CpG oligonucleotide analogs containing hydrophobic T analogs with enhanced immunostimulatory activity.
A vaccine composition as claimed in any of the preceding claims wherein the CpG oligonucleotide is,.
Specifically, a CpG oligonucleotide can contain a modified cytosine.
In a preferred embodiment, any of the vaccine disclosed herein comprises approximately 1 mg CpG oligonucleotide.
In an embodiment, the CpG oligonucleotide of the present invention is chemically modified.
Figure 8 shows a graph depicting more rapid and sustained activation than CpG oligonucleotide.
Thus, CpG oligonucleotide can induce mucosal immunity at distant mucosal sites.
In some embodiments the anti-viral agent and the CpG oligonucleotide of the disclosure are linked.
The composition according to claim 9, wherein the adjuvant comprises aluminum hydroxide gel and a CpG oligonucleotide.
Alternatively, the CpG oligonucleotide may be administered with a boost dose of antigen.
SBAS 2 formulations were prepared as above, but without the addition of the CpG oligonucleotide.
The immunostimulatory CpG oligonucleotide has a sequence including at least the following formula,.
Further activation of IPCs occurred when GM-CSF and CpG oligonucleotide were present together.
This result demonstrates CpG oligonucleotide induces human IPCs to secrete multiple subspecies of IFN-a.
Other preferred adjuvants are bacterial DNA based adjuvants, such as adjuvants including CpG oligonucleotide sequences.
For facilitating uptake into cells, CpG oligonucleotide have a minimum length of 6 nucleotide residues.
The composition of claim 1, wherein said adjuvant is said CpG oligonucleotide.
This result demonstrates that CpG oligonucleotide induces IPCs to produce high amounts of IL-8.
The method according to clause C148, wherein the adjuvant includes aluminum hydroxide gel and a CpG oligonucleotide.
The CpG oligonucleotide and / or the antigen may be administered alone e . g.
A TLR-9 agonist for use in the present invention is a CpG Oligonucleotide.
Preferably the CpG oligonucleotide is in the range of about 8 to 30 bases in size.
SEQ ID NO, 1 shows the nucleotide sequence of a CpG oligonucleotide.
Preferably, the CpG oligonucleotide is constructed so that the 5 ' end is accessible for receptor recognition.
The vaccine composition of any one of claims 1-10, wherein said P-class CpG oligonucleotide is modified.
The combination of CpG oligonucleotide and GM-CSF produced a dramatic survival rate of 70 %.
Freund 's incomplete adjuvant, Montanide, poly I, C, a derivative thereof, and CpG oligonucleotide are particularly preferable.
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