Examples of 'heavy chain constant region' in a sentence
Meaning of "heavy chain constant region"
heavy chain constant region: In immunology, refers to the part of an antibody molecule that is involved in binding to other immune system components. This region plays a crucial role in the immune response and antibody function
How to use "heavy chain constant region" in a sentence
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heavy chain constant region
The immunoglobulin mu heavy chain constant region was used.
The heavy chain constant region comprises three domains.
An immunoglobulin moiety may comprise a heavy chain constant region.
Preferably the heavy chain constant region is derived from an antibody locus.
The linker also included a standard heavy chain constant region.
Preferably the heavy chain constant region is derived from an immunoglobulin locus.
These are dictated by the structure of the heavy chain constant region.
The heavy chain constant region may further comprise a hinge region.
An immunoglobulin moiety that comprises a heavy chain constant region of an immunoglobulin.
The heavy chain constant region is primarily responsible for effector function.
Fc fragments are generated entirely from the heavy chain constant region of an immunoglobulin.
And a heavy chain constant region deriving from human IgG and a human constant light chain region.
It is possible to fuse the entire heavy chain constant region to the lectin sequence.
The immunoglobulin constant region of the present invention includes a heavy chain constant region.
The number of heavy chain constant region domains will depend on the isotype.
See also
Within another related embodiment the second portion is an immunoglobulin heavy chain constant region.
The sequences of human heavy chain constant region genes are known in the art.
An " isotype " is a class of antibodies defined by the heavy chain constant region.
In one embodiment the human heavy chain constant region is a human IgG constant region.
In one embodiment, the second portion is an immunoglobulin heavy chain constant region.
The immunoglobulin heavy chain constant region is an Fc region.
In some embodiments, the immunoglobulin constant region is a heavy chain constant region.
A preferred human heavy chain constant region is IgG3.
Preferably, a humanized or chimeric antibody comprises an IgG heavy chain constant region.
Human heavy chain constant region derived from IgG4.
A domain, of an immunoglobulin heavy chain constant region.
And the heavy chain constant region is selected from the group consisting of,.
The mouse would further comprise a mouse heavy chain constant region modification as described herein.
In some embodiments, a heavy chain comprises at least a portion of a heavy chain constant region.
It is possible to fuse the entire heavy chain constant region to the adhesin sequence.
An IgG1 heavy chain constant region is one example of a suitable heavy chain constant region.
For example, the immunoglobulin moiety can comprise a heavy chain constant region.
In some aspects, the heavy chain constant region of an antibody is afucosylated.
In some embodiments, a mutated version of the immunoglobulin gamma heavy chain constant region is provided.
In further embodiments, the heavy chain constant region or fragment thereof is a human IgG1.
A second polynucleotide encoding an immunoglobulin moiety that comprises a heavy chain constant region of an immunoglobulin ;.
Preferably, the heavy chain constant region is an IgG1 heavy chain constant region.
Accordingly, each heavy chain may have identical heavy chain constant region sequences.
Typically, the heavy chain constant region is human or a modified form of a human constant region.
In certain embodiments, the above-described binding molecules comprise a heavy chain constant region or fragment thereof.
In one example, the heavy chain constant region lacks the c-terminal lysine residue.
Use according to any previous claim, wherein the immunoglobulin moiety comprises a heavy chain constant region.
As is known, each immunoglobulin heavy chain constant region includes four or five domains.
The antibody of Claim 3, wherein the antibody comprises a heavy chain constant region.
As is known, each immunoglobulin heavy chain constant region comprises four or five domains.
Plasmid pAB1 was used as a source of DNA encoding the IgG1 heavy chain constant region.
In some specific aspects, the heavy chain constant region is an IgG constant region.
The use of E 5, wherein the immunoglobulin moiety comprises a human heavy chain constant region.
In some cases, the human heavy chain constant region is modified for this purpose.
Each heavy chain comprises a heavy chain variable region ( HCVR ) and a heavy chain constant region.
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