Examples of 'modified nucleoside' in a sentence
Meaning of "modified nucleoside"
modified nucleoside - a nucleoside molecule altered from its original structure
How to use "modified nucleoside" in a sentence
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modified nucleoside
The modifier can be introduced by use of a modified nucleoside as a phosphoramidite.
A modified nucleoside may have a modified sugar and an unmodified nucleobase.
The method comprises attaching a modified nucleoside to control pore glass.
D is a modified nucleoside comprising a modification different from the nucleoside adjacent to it.
The definition of a nucleotide in the current invention includes a natural or modified nucleoside phosphate.
The dITP is a modified nucleoside for purposes of the present invention.
In one embodiment, the minor groove binder is a modified nucleoside.
A modified nucleoside may have a modified sugar and a modified nucleobase.
In another embodiment the incorporated modified nucleoside is derived from a correspondingly modified deoxy nucleoside.
In certain embodiments, the gap comprises one modified nucleoside.
Queuosine is a modified nucleoside that is present in certain tRNAs in bacteria and eukaryotes.
The modifier can be introduced by use of a modified nucleoside as a DNA synthesis support.
Values for measured modified nucleoside content were determined based on quantitation of the HPLC chromatograms.
In a particular embodiment of the present invention, a modified nucleoside is represented by the formula,.
D is a modified nucleoside comprising a modification different from A.
See also
In another embodiment, the pseudouridine or a modified nucleoside is outside the siRNA sequence.
A modified nucleoside phosphoramidite represented by the formula,.
In certain embodiments, a modified nucleoside is a bicyclic nucleoside.
Modified nucleoside phosphoramidates of the present invention are non-naturally occurring.
In certain such embodiments, a modified nucleoside is a stabilizing nucleoside.
These modified nucleoside triphosphates are also termed herein as ( nucleotide ) analogs.
In another example, the pseudouridine or a modified nucleoside is within the siRNA sequence.
For example, a modified nucleoside or nucleotide can have a modified sugar and a modified nucleobase.
In certain embodiments, the at least one tetrahydropyran modified nucleoside has the structure,.
In certain embodiments, a modified nucleoside comprises a modified heterocyclic base moiety.
In certain embodiments, the gap comprises one modified linkage and one modified nucleoside.
Compound NS2 illustrates a modified nucleoside comprising a modified base comprising a phosphate moiety.
The term synthetic nucleoside, for the purpose of the present invention, refers to a modified nucleoside.
In another embodiment, the modified nucleoside is ψ ( pseudouridine ).
The composition for use according to claim 6, wherein the therapeutic nucleic acid contains a modified nucleoside.
In certain embodiments, a modified nucleoside is a sugar-modified nucleoside.
In another embodiment, the RNA molecule or oligoribonucleotide molecule comprises a modified nucleoside.
In certain embodiments, a modified nucleoside is a non-bicyclic nucleoside.
The present application discloses an in vitro - transcribed RNA molecule, comprising a pseudouridine or a modified nucleoside.
In a preferred embodiment, a modified nucleoside is incorporated at the 5 ' terminus as described above.
In another embodiment, the in vitro-synthesized RNA molecule further comprises a pseudouridine or a modified nucleoside.
In certain embodiments, a modified nucleoside comprises a sugar moiety other than ribose and 2 ' - deoxyribose.
Where the circular IMP is synthesized using recombinant or chemical methods, a modified nucleoside is suitable.
In some embodiments, the modified nucleoside is a non-natural pyrimidine or purine nucleoside, as herein described.
In another example, the in vitro - synthesized RNA molecule further comprises a pseudouridine or a modified nucleoside.
In another embodiment, the modified nucleoside is cytidine ( C ) in addition to uridine.
In another disclosure, the in vitro - synthesized RNA molecule further comprises a pseudouridine or a modified nucleoside.
Use of modified nucleoside 5 ' - triphosphates in primer extension and PCR.
In another embodiment, the present invention provides an in vitro-transcribed RNA molecule, comprising a modified nucleoside.
In another embodiment the modified nucleoside is guanosine ( G ).
The modified nucleoside phosphoramidites were obtained for example Glen Research ( Sterling, VA ).
In another example of the disclosure, the modified nucleoside is adenine ( A ).
The modified nucleoside is synthesized in 7 steps with poor yield, less than 5 %.
In another embodiment the modified nucleoside is guanine ( G ).
In certain embodiments, each nucleoside of the 5 ' - wing of a gapmer is a non-bicyclic modified nucleoside.
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