Examples of 'modified nucleosides' in a sentence
Meaning of "modified nucleosides"
Modified nucleosides: These are nucleosides where the structure has been altered by adding specific chemical groups. They are commonly used in biochemical research and drug development
How to use "modified nucleosides" in a sentence
Basic
Advanced
modified nucleosides
Still another strategy employs modified nucleosides.
Certain such modified nucleosides are known.
Preferred monomeric subunits comprise nucleosides and modified nucleosides.
These modified nucleosides are then used to add the conductive oligomers.
The present invention provides oligonucleotides comprising modified nucleosides.
Modified nucleosides were incorporated at specific sites using normal coupling cycles.
Further suppression was observed when the proportion of modified nucleosides was increased.
Modified nucleosides for the treatment of viral infections and abnormal cellular proliferation.
Oligonucleotides are chemically synthesized from protected phosphoramidites of natural or chemically modified nucleosides.
RNA containing modified nucleosides and methods of use thereof.
The present invention provides oligonucleotides for use in therapy comprising modified nucleosides.
The modified nucleosides are used to introduce biophysical probes into RNA.
Such mutants permit the cell to maintain nucleic acid having modified nucleosides therein.
Modified Nucleosides and Nucleotides The present disclosure provides for modified nucleosides and nucleotides.
These findings provide a novel in vitro system for production of RNA molecules with modified nucleosides.
See also
Certain Modified Nucleosides Provided herein are oligomeric compounds comprising modified nucleosides.
Backbone Modifications The phosphate backbone may further be modified in the modified nucleosides and nucleotides.
The structures of these modified nucleosides can be diagrammed as,.
Analysis of IVT mRNA synthesis incorporating modified nucleosides.
Modified nucleosides comprise a modified sugar moiety and / or a modified nucleobase.
In certain embodiments, the gap comprises four modified nucleosides.
The modified nucleosides of the present invention are non-naturally occurring.
In certain embodiments, the gap comprises three modified nucleosides.
In certain instances, modified nucleosides may be useful for incorporation into oligonucleotides.
In certain embodiments, the gap comprises two modified nucleosides.
Such modified nucleosides may include a modified sugar and / or a modified nucleobase.
In certain embodiments, the gap comprises one or more modified nucleosides.
In certain embodiments, modified nucleosides comprise a modifed sugar moirty and / or modifed nucleobase.
In certain embodiments, a modified oligonucleotide comprises one or more modified nucleosides.
Other modified nucleosides and modified oligonucleotides may be synthesized by employing well-known synthetic techniques.
Monomer subunits include, without limitation, nucleosides and modified nucleosides.
Abstract, Modified nucleosides represent the cornerstone of antiviral chemotherapy.
In certain embodiments, the present disclosure provides oligonucleotides comprising modified nucleosides.
For attachment to a ribose, a preferred embodiment utilizes modified nucleosides to attach the electron transfer moieties.
In certain embodiments, the present invention provides oligonucleotides comprising modified nucleosides.
The present disclosure also provides kits including modified nucleosides and / or nucleotides labelled with dyes.
There are also disclosures with regard to glucitol or mannitol-based modified nucleosides.
In certain such embodiments, the modified nucleosides do not support RNase H activity.
In certain embodiments, the gap comprises two modified linkages and two or more modified nucleosides.
Certain Modified Nucleosides In certain embodiments, antisense oligonucleotides comprise one or more modified nucleosides.
The latter two documents disclose the synthesis of modified oligonucleotides having incorporated hexitol-based modified nucleosides.
TABLE 1 Modified nucleosides present in RNAs.
The synthetic, modified RNA molecule may comprise at least two modified nucleosides.
In certain instances, modified nucleosides comprise a substituent at the 2 ' position of the sugar.
In certain embodiments, antisense compounds that utilize RNase H comprise one or more modified nucleosides.
In certain instance, modified nucleosides are incorporated into oligonucleosides at the 5 ' - end of the oligonucleotide.
There are more than 100 other naturally occurring modified nucleosides.
In certain embodiments, the 2 ' - MOE modified nucleosides are arranged in a gapmer motif.
In certain embodiments, such antisense compounds comprise at least one block of 1-8 modified nucleosides.
As used herein, “ bicyclic nucleosides ” refer to modified nucleosides comprising a bicyclic sugar moiety.
You'll also be interested in:
Examples of using Nucleosides
Show more
All of the dioxolanyl nucleosides were enantiomerically pure
Nucleosides were dried by evaporation of portions of dry pyridine
Purine and pyrimidine nucleosides are conditionally essential
Examples of using Modified
Show more
A modified sine wave is generated by this conversion
This warranty may be modified only by RedMax
This modified virus seems to really work
