Examples of 'light chain locus' in a sentence
Meaning of "light chain locus"
light chain locus: Light chain locus refers to a specific genetic location where genes responsible for producing light chains of antibodies are located
How to use "light chain locus" in a sentence
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light chain locus
Deletion of the mouse λ light chain locus.
The human λ light chain locus is richly diverse.
Deletion of the mouse k light chain locus.
The mouse k light chain locus is strikingly different.
The transgenic animal may comprise a human k light chain locus.
The λ light chain locus may be deleted in part or completely.
The mouse may further comprise a disabled endogenous immunoglobulin light chain locus.
Alternatively, the light chain locus may be the first.
The animal may be heterozygous or homozygous for a substantially inactivated endogenous λ light chain locus.
In a specific embodiment, the mouse light chain locus is a k locus.
The human λ light chain locus may be a substantially full-length germline sequence.
The ES cell or progeny may comprises a substantially complete germline human λ light chain locus.
In a specific aspect, the mouse light chain locus is a k locus.
The ES cell may further comprise a human heavy chain locus and a human k light chain locus.
In a specific aspect, the λ light chain locus is deleted in whole or in part.
See also
In one aspect, the mouse comprises a functional λ light chain locus.
In a specific embodiment, the λ light chain locus is deleted in whole or in part.
In one embodiment, the mouse comprises a nonfunctional k light chain locus.
Alternatively, the light chain locus may be the first to be inactivated.
In another aspect, the endogenous mouse light chain locus is a λ locus.
The humanized light chain locus is used for the generation of transgenic animals . Example 9,.
Figure 5 is a schematic depiction of the rabbit immunoglobulin light chain locus.
In a specific aspect, the endogenous λ light chain locus is deleted in part or completely.
In some apsects, the mouse comprises a functional λ light chain locus.
In some such methods, the human kappa light chain locus is the inserted KCo5 transgene.
In one aspect, the mouse comprises a nonfunctional λ light chain locus.
Example 8 Construction of a humanized rabbit light chain locus containing multipe human Vk elements.
In some embodiments, the mouse comprises a functional λ light chain locus.
In a related embodiment, the Ig light chain locus further comprises a human Igk constant region.
In one embodiment, the mouse comprises a nonfunctional λ light chain locus.
In one embodiment, the human Igλ light chain locus comprises the entire human Igλ locus.
In one embodiment, the mouse comprises a functional λ light chain locus.
The k light chain locus is spread out over three clusters on chromosome 2 ( Fig . 3 ).
In one aspect, the endogenous mouse light chain locus is a k locus.
In certain other embodiments, the endogenous immunoglobulin locus is a light chain locus.
In another embodiment, the endogenous mouse light chain locus is a λ locus.
In some aspects, the genetically modified immunoglobulin locus is a light chain locus.
In one embodiment, the endogenous mouse light chain locus is a k locus.
Still further, the transgenic animal comprises a human k light chain locus.
In one aspect, the mouse immunoglobulin light chain locus is a mouse k locus.
In one embodiment, the mouse further comprises a disabled endogenous immunoglobulin light chain locus.
The mouse according to claim 1 in which the k light chain locus is functionally silenced.
The genetic modification, in various aspects, comprises a deletion of the endogenous k light chain locus.
Alternatively, only a portion of the human λ light chain locus may be used.
In one embodiment, the transgenic animal comprises an inactivated endogenous Ig light chain locus.
In some certain aspects, the endogenous immunoglobulin light chain locus is a k light chain locus.
In one embodiment, the light chain is expressed from an endogenous light chain locus.
The transgenic animal may comprise a human λ light chain locus of approximately 0.9 Mb.
In one embodiment, the mouse may comprise a non-functional lambda light chain locus.
According to this embodiment, preferably the endogenous kappa ( k ) light chain locus is functionally silenced.
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